It can also improve weight gain, survival, hepatopancreas myo-inositol content, antioxidant capacity, and nonspecific immune performance in the Chinese mitten crab Eriocheir Sinensis and inhibit the expression of genes related to lipid synthesis while promoting the expression of genes related to lipid export, resulting in lower lipid content (Bu et al., 2020). As seen in previous studies on crustaceans, myo-inositol supplementation in feed can improve survival, weight gain, protein utilization efficiency, and myo-inositol in the hepatopancreas in grass shrimp Penaeus monodon but decrease hepatopancreatic lipid and hepatosomatic index (Shiau and Su, 2004). Therefore, adding myo-inositol to feed can meet the nutritional requirements of aquatic animals. The deficiency of myo-inositol leads to slow growth, low nutrient utilization, and lesions in aquatic animals (Shirmohammad et al., 2016). However, the myo-inositol synthesized in some aquatic animals cannot meet their normal physiological and metabolic requirements (Shiau and Su, 2004). In addition, the intestinal microbiota is also a source of myo-inositol in abalone and olive flounder (Lee et al., 2008 Mai et al., 2001). Some animals can synthesize myo-inositol de novo using glucose-6-phosphate through the MIB pathway(Geiger and Jin, 2006). Therefore, studying the physiological functions of myo-inositol can contribute to the understanding of enhancing the health and growth of animals. These target proteins can influence growth, metabolism, health, and cellular division. For example, yes-associated protein ( YAP), forkhead box O3 ( Foxo3), and murine double minute2 ( Mdm2) kappa B kinase ( IKKa) can inhibit apoptosis (Basu et al., 2003), cell death (Carracedo and Pandolfi, 2008), oxidative stress (Beyfuss and Hood, 2018), and nuclear translocation of NF-κB (Carracedo and Pandolfi, 2008), respectively. In addition, phosphoinositides regulate multiple target protein functions. It is distributed in mammalian brains and other tissues and participates in transmembrane signal transduction in response to various hormones, neurotransmitters, and osmoregulation via phospholipids or phosphorylation (Parthasarathy et al., 2006). Myo-inositol, a carbocyclic sugar, is involved in various important physiological processes in animals. This study has suggested that myo-inositol may promote growth in L. The highest growth was achieved with the inclusion of 528 mg/kg dietary myo-inositol. Metabolome and transcriptome analyses revealed that myo-inositol significantly affected glycerophospholipid metabolism, transport and catabolism in lysosomes, pancreatic secretion, and bile secretion pathways. On the other hand, serum triglyceride, total cholesterol, and low-density lipoprotein contents in the control group were significantly lower than those in the other groups, and glucose content in the hepatopancreas in the control group was significantly lower than that in the 20 mg/kg myo-inositol groups.
The maximal hepatosomatic index was found in the 1030 mg/kg myo-inositol group. The weight gain and conditioning factors of shrimp fed myo-inositol were significantly higher than those of the 20 mg/kg myo-inositol group.
#Download cytoscape 2.8 trial
An 8-week trial was conducted to comparatively evaluate the effects of 6 levels of dietary myo-inositol (20, 528, 1030, 2060, 31 mg/kg diet) on growth performance, body composition, serum metabolite composition, hepatopancreatic metabolite content, and digestive enzyme activity in juvenile Pacific white shrimp Litopenaeus vannamei (0.78 ± 0.039 g). However, the optimal requirements of myo-inositol and the mechanisms by which myo-inositol is involved in nutritional regulation in crustaceans are unclear. Myo-inositol serves as an essential nutrient in many animal species.
0 kommentar(er)
